Pope Benedict is appointing 22 new cardinals at the Vatican on Saturday, with his choices for the lofty role likely to influence who will be appointed as the next pontiff.

The Vatican named the new cardinals last month, but will be officially appointed in a special ceremony at St. Peter's Basilica.

Among those to be elevated to the College of Cardinals are New York Archbishop Timothy Dolan, cementing his standing as the top Catholic in the United States, and Archbishop Edwin F. O'Brien of Baltimore.

Others include Archbishop Thomas Collins, from Toronto, as well as the Bishop of Hong Kong, John Tong Hon, and Major Archbishop George Alencherry from India

Senior clerics from Germany, the Netherlands, the Czech Republic, Romania and Brazil are also represented, as well as several from Italy.

The College of Cardinals was established in 1150. Its main role is to advise the current Pope and pick his successor.

"This is the most exclusive club in the Catholic Church," said John Allen, CNN's Vatican analyst. "In many cases, you also become, at least informally, a candidate to be the next pope, because the next pope will almost certainly come from the roughly 120 cardinals under the age of 80."

Once a cardinal reaches 80, he is no longer able to participate in the election of the pope or enter the secret conclave where cardinals gather when the time comes to select the next pope, typically upon the prior pope's death.

The new cardinals will each profess their faith and swear an oath of obedience to Pope Benedict and his successors during Saturday's ceremony, called the Consistory, at the Vatican.

They will then walk one by one to the pontiff, kneel in front of him and receive the traditional red hat, a gold ring, and a document with the name of the cardinal's titular church in Rome. The pope and newly-created cardinal will then embrace.

Pope Benedict will also announce seven new saints, including the first Native American saint, a 17th-Century Mohawk woman called Kateri, or Catherine, Tekakwitha, who was a Catholic convert.

Existing members of the College of Cardinals and the new cardinals-elect came together for a day of prayer and reflection Friday, in preparation for the ceremony, according to the Holy See Press Office.

Dolan addressed the gathering on the subject of evangelization, saying there was a need to challenge a growing secularization of society.